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Saturday, March 15, 2008
Why are we made of only left-handed amino acids? A molecular concept of Life.
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Most biomolecules are "chiral", that is to say, they exist in two left and right-handed mirror-image forms. However, biology onl...
Saturday, March 8, 2008
The Histamine H4 Receptor: Drug Discovery in the Post-genomic Era
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The Histamine H4R receptor is the most recently identified G-protein coupled receptor, with little homology to the classical pro-inflammator...
Saturday, February 16, 2008
Novel Reactions: Are anymore waiting to be Discovered?
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Inspired by Barton's landmark total synthesis of Usnic acid, a method was devised by Baran for the direct oxidative coupling of indoles ...
Saturday, February 2, 2008
Fluorine in Drug Discovery
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The importance of Fluorine in medicinal chemistry is well recognized. Indeed, an increasing number of drugs on the market contain Fluorine...
Sunday, January 27, 2008
The Negative Side of Boran
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According to researchers Makoto Yamashita and his colleagues at the University of Tokyo, Japan, a molecule that hosts a negatively-charged b...
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