Monday, December 24, 2018

Artificial polymerases

The development of synthetic catalysts that has parallel enzymatic efficiency in terms of rate and turnover is still a challenge in chemistry. The de novo design of biochemical system in molecular matrix is fascinating and quite challenging for future synthetic catalysis. We recently used non-covalent interaction approach to create nano-sized artificial enzymes for the size, shape, stereo and enantio-selective synthesis of small molecules and polymers.
Graphical abstract: Directional threading of a chiral porphyrin cage compound onto viologen guests 

These biomimetic systems not only provide fresh insight into elucidating the catalytic mechanism of natural enzymes but also demonstrate the underlying principles in structure-based catalysis. The newly discovered chiral catalytic host can move along polymer chains in a single direction like natural enzymes, polymerases, and ribosomes. Such synthetic catalytic machines could be used for the synthesis of sequence controlled polymers as well as for data storage.