Saturday, February 16, 2008

Novel Reactions: Are anymore waiting to be Discovered?

Inspired by Barton's landmark total synthesis of Usnic acid, a method was devised by Baran for the direct oxidative coupling of indoles and pyrroles to a range of carbonyl compounds. ( Baran et al, J. Am. Chem. Soc. 2007, 129, 12857-69 )

when one examines the piece of work to which such a description has been applied it often turns out to contains only a minor improvement on a well known reaction or a new application of old technique.

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