Replacement of C-H bond with fluorine (C-F) has unique advantages in drug development and tracers for Positron Emission Tomography (PET), a powerful technology for noninvasive molecular imaging.
Introducing fluorine group directly onto a saturated ring system is very difficult; also there may be functional groups that are not compatible with fluorination.
Recently, Ritter and co-workers reported a regioselective, functional group tolerant fluorination reaction of aryl boronic acids mediated by palladium complex. This process is ideally suited for introducing fluorine substituents at a late stage for aryl fluoride synthesis.
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