Thursday, July 17, 2008

Fluorination reaction of aryl boranic acids

Replacement of C-H bond with fluorine has special advantages in drug development and tracers for Positron Emission Tomography (PET), a powerful technology for noninvasive molecular imaging.

Introducing Fluorine group directly onto a saturated ring system is very difficult and there also may be functional groups that are not compatible with fluorination.

Recently Tobias Ritter reported (DOI: 10.1002/anie.200802164) a regioselective, functional group tolerant fluorination reaction of aryl boranic acids mediated by palladium complex.

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