Monday, May 21, 2007

Reduction of amino acids

There are many ways to reduce amino acids to amino alcohols, using sodium boro hydride and Iodine in THF is an excellent process.
which is not only non expensive and safety perspective but the work up is much easier (compared to LiAlH4) Iodine oxidizes the hydride giving a mole of H2 and generating BH3 in situ.
All that borane actually the stuff that reduce the acid to alcohol

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