A racemic switch or chiral switch is the redevelopment in the single-enantiomer form of a drug that was first approved as a racemates (racemic mixture). Sometimes, the pharmaceutical activity of a racemic mixture is present only in one enantiomer, and the other is inactive, or the other enantiomer has an undesired activity from the first.
OmeprazoleFor exmaple, Omeprazole is an Antiulcer drug (AstraZeneca) marketed in the U.S. as a racemic drug in 1995. It s a racemic mixture of R-omeprazole and S-omeprazole. Since its patent ran out in 2002 and the pharmacological activity lies in (S)-enantiomer, the company has patented now (S)-omeprazole named as esomeprazole.
8 comments:
Where is the stereogenic carbon in that molecule?
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