Friday, September 7, 2007

"Racemic Switch"

A "racemic switch" is the redevelopment in single-enantiomer form of a drug that was first approved as a racemate. Sometimes, the pharmaceutical activity is in only one enantiomer and the other is inactive, or the "other" enantiomer has a different kind of activity from the first.
Omeprazole

Omeprazole is a Antiulcer drug (AstraZeneca) .It was marketed in U.S. as a racemic drug in 1995. The patent ran out in 2002. Since pharmacological property lies in (S)-enantiomer, the company has patented now (S)-enantiomer.

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Where is the stereogenic carbon in that molecule?

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